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Harnessing zebrafish for the study of white blood cell development and its perturbation

journal contribution
posted on 2004-09-01, 00:00 authored by S Onnebo, S Yoong, Alister WardAlister Ward
Considerable progress has been made in understanding the molecular basis of normal white blood cell development and its perturbation in disease through the use of clinical studies and traditional animal and cell line models. Despite this, however, many questions are still being answered and white blood cell disorders, including leukemia and lymphoma, remain a significant health problem. The zebrafish (Danio rerio) has emerged as a powerful alternative vertebrate model for the study of development and disease. We review the recent application of zebrafish to the study of white blood cell development and its disruption, particularly leukemogenesis. Such studies have highlighted the overall conservation of these processes throughout vertebrates, and establish zebrafish as a useful experimental model. This organism is now poised to make an important contribution to our understanding of the underlying genetic control of white blood cell development and its disruption, as well as the identification of new therapeutic agents.

History

Journal

Experimental hematology

Volume

32

Issue

9

Pagination

789 - 796

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0301-472X

eISSN

1873-2399

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2004, International Society for Experimental Hematology