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High genetic diversity of plasmodium vivax on the north coast of papua new guinea
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posted on 2013-07-01, 00:00 authored by A Arnott, C Barnadas, N Senn, P Siba, I Mueller, J C Reeder, Alyssa BarryAlyssa BarryDespite having the highest Plasmodium vivax burden in the world, molecular epidemiological data from Papua New Guinea (PNG) for this parasite remain limited. To investigate the molecular epidemiology of P. vivax in PNG, 574 isolates collected from four catchment sites in East Sepik (N = 1) and Madang (N = 3) Provinces were genotyped using the markers MS16 and msp1F3. Genetic diversity and prevalence of P. vivax was determined for all sites. Despite a P. vivax infection prevalence in the East Sepik (15%) catchments less than one-half the prevalence of the Madang catchments (27-35%), genetic diversity was similarly high in all populations (He = 0.77-0.98). High genetic diversity, despite a marked difference in infection prevalence, suggests a large reservoir of diversity in P. vivax populations of PNG. Significant reductions in transmission intensity may, therefore, be required to reduce the diversity of parasite populations in highly endemic countries such as PNG.© 2013 by The American Society of Tropical.
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Journal
American Journal of Tropical Medicine and HygieneVolume
89Issue
1Pagination
188 - 194Publisher
American Society of Tropical Medicine and HygieneLocation
[Northbrook, Ill.]Publisher DOI
ISSN
0002-9637Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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