dhar-howhostregulation-2016.pdf (127.66 kB)
How host regulation of Helicobacter pylori-induced gastritis protects against peptic ulcer disease and gastric cancer
journal contribution
posted on 2016-01-01, 00:00 authored by Poshmaal DharPoshmaal Dhar, G Z Ng, P SuttonThe bacterial pathogen Helicobacter pylori is the etiological agent of a range of gastrointestinal pathologies including peptic ulcer disease and the major killer, gastric adenocarcinoma. Infection with this bacterium induces a chronic inflammatory response in the gastric mucosa (gastritis). It is this gastritis that, over decades, eventually drives the development of H. pylori-associated disease in some individuals. The majority of studies investigating H. pylori pathogenesis have focused on factors that promote disease development in infected individuals. However, an estimated 85% of those infected with H. pylori remain completely asymptomatic, despite the presence of pathogenic bacteria that drive a chronic gastritis that lasts many decades. This indicates the presence of highly effective regulatory processes in the host that, in most cases, keeps a check on inflammation and protect against disease. In this minireview we discuss such known host factors and how they prevent the development of H. pylori-associated pathologies.
History
Journal
American Journal of Physiology - Gastrointestinal and Liver PhysiologyVolume
311Issue
3Pagination
G514 - G520Publisher
AMER PHYSIOLOGICAL SOCLocation
United StatesPublisher DOI
Link to full text
ISSN
0193-1857eISSN
1522-1547Language
EnglishPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2016, the American Physiological SocietyUsage metrics
Keywords
Science & TechnologyLife Sciences & BiomedicineGastroenterology & HepatologyPhysiologyHelicobacter pylorihost factorsgastritisimmune suppressionACTIVATED-RECEPTOR-GAMMANF-KAPPA-BT-CELLSINFLAMMATORY RESPONSESIMMUNE CELLSINFECTIONMUCINMICEMUCOSACOLONIZATIONHelicobacter InfectionsHumansPeptic UlcerStomach NeoplasmsPhysiology
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