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Human neuronal cells : epigenetic aspects
journal contribution
posted on 2013-01-01, 00:00 authored by JESSICA KUKUCKA, T Wyllie, Justin Read, Lauren Mahoney, Cenk SuphiogluCenk SuphiogluHistone acetyltransferases (HATs) and histone deacetylases (HDACs) promote histone posttranslational modifications, which lead to an epigenetic alteration in gene expression. Aberrant regulation of HATs and HDACs in neuronal cells results in pathological consequences such as neurodegeneration. Alzheimer's disease is the most common neurodegenerative disease of the brain, which has devastating effects on patients and loved ones. The use of pan-HDAC inhibitors has shown great therapeutic promise in ameliorating neurodegenerative ailments. Recent evidence has emerged suggesting that certain deacetylases mediate neurotoxicity, whereas others provide neuroprotection. Therefore, the inhibition of certain isoforms to alleviate neurodegenerative manifestations has now become the focus of studies. In this review, we aimed to discuss and summarize some of the most recent and promising findings of HAT and HDAC functions in neurodegenerative diseases.
History
Journal
Biomolecular conceptsVolume
4Issue
4Pagination
319 - 333Publisher
Walter de Gruyter GmbH & Co. KGLocation
Berlin, GermanyPublisher DOI
ISSN
1868-5021Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2013, Walter de Gruyter GmbH & Co. KGUsage metrics
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