dekoningward-illuminatinghow-2019.pdf (755.06 kB)
Illuminating how malaria parasites export proteins into host erythrocytes
journal contribution
posted on 2019-04-01, 00:00 authored by Kat MatthewsKat Matthews, Ethan L Pitman, Tania De Koning-WardTania De Koning-WardPlasmodium parasites that cause the disease malaria have developed an elaborate trafficking pathway to facilitate the export of hundreds of effector proteins into their host cell, the erythrocyte. In this review, we outline how certain effector proteins contribute to parasite survival, virulence, and immune evasion. We also highlight how parasite proteins destined for export are recognised at the endoplasmic reticulum to facilitate entry into the export pathway and how the effector proteins are able to transverse the bounding parasitophorous vaculoar membrane via the Plasmodium translocon of exported proteins to gain access to the host cell. Some of the gaps in our understanding of the export pathway are also presented. Finally, we examine the degree of conservation of some of the key components of the Plasmodium export pathway in closely related apicomplexan parasites, which may provide insight into how the diverse apicomplexan parasites have adapted to survival pressures encountered within their respective host cells.
History
Journal
Cellular microbiologyVolume
21Issue
4Article number
e13009Pagination
1 - 10Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
Link to full text
eISSN
1462-5822Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, John Wiley & Sons LtdUsage metrics
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Keywords
Plasmodium parasitesmalariaerythrocyteparasite survivalimmune evasionvirulenceendoplasmic reticulumScience & TechnologyLife Sciences & BiomedicineCell BiologyMicrobiologyRED-BLOOD-CELLSDENSE GRANULE PROTEINSPLASMODIUM-FALCIPARUMPTEX COMPONENTPLASMEPSIN VTRANSLOCONMEDIATECOMMUNICATIONTHIOREDOXIN-2Microbiology
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