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Increased perseverative errors following high-definition transcranial direct current stimulation over the ventrolateral cortex during probabilistic reversal learning
journal contribution
posted on 2019-07-01, 00:00 authored by Natalia Albein-UriosNatalia Albein-Urios, Henry Chase, Luke Clark, Melissa KirkovskiMelissa Kirkovski, Charlotte Davies, Peter EnticottPeter EnticottBACKGROUND: The prefrontal cortex regulates behavioural adaptation in response to feedback. However, the causal role of different prefrontal regions remains unclear, based on indirect evidence derived from functional neuroimaging. Neuroimaging studies show dorsomedial prefrontal activation during feedback monitoring, whereas the ventrolateral prefrontal cortex engages during behavioural adaptation (shifting). OBJECTIVE: We used high-definition transcranial direct current stimulation (HD-tDCS) to elucidate the roles of the ventrolateral prefrontal cortex (vlPFC) and the dorsomedial prefrontal cortex (dmPFC) in behaviour change, using a probabilistic reversal learning task (PRLT). METHOD: Fifty-two healthy adults were randomly assigned to receive cathodal HD-tDCS to inhibit the vlPFC or the dmPFC versus sham stimulation, prior to completing the PRLT. The outcome measures were the number of perseverative errors and the electroencephalography (EEG) signals of feedback-related negativity (FRN) in the PRLT. We hypothesised that inhibition of the vlPFC would be specifically associated with more perseverative errors and weaker FRNs. RESULTS: We found that vlPFC inhibition was associated with higher perseverative errors compared to sham and dmPFC stimulation conditions. Although there were no statistically significant differences in FRN amplitudes, the effect sizes indicate an association between inhibition of the vlPFC and lower FRN amplitudes. CONCLUSION: Our findings support a causal role of the vlPFC on feedback-based behavioural adaptation, which is critical for adaptive goal-driven behaviour.
History
Journal
Brain stimulationVolume
12Issue
4Season
July-AugustPagination
959 - 966Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
1876-4754Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, ElsevierUsage metrics
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Cathodal stimulationFeedback-related negativityHigh-definition transcranial direct current stimulationPerseverative errorsProbabilistic reversal learningVentrolateral prefrontal cortexScience & TechnologyLife Sciences & BiomedicineClinical NeurologyNeurosciencesNeurosciences & NeurologyDORSOLATERAL PREFRONTAL CORTEXORBITOFRONTAL CORTEXBEHAVIORAL FLEXIBILITYDIFFERENTIAL CONTRIBUTIONSANTERIOR CINGULATECOGNITIVE CONTROLDECISION-MAKINGREWARDFEEDBACKINHIBITION
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