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Influence of base on nitro-aldol (Henry) reaction products for alternative clandestine pathways
journal contribution
posted on 2016-01-01, 00:00 authored by Luke Andrighetto, Luke HendersonLuke Henderson, J R Pearson, Paul Stevenson, Xavier ConlanXavier ConlanAustralian clandestine drug laboratories are constantly utilising alternative methods to produce methamphetamine, in part as restrictions are placed by Government on, for example, chemicals such as phenyl-2-propanone (P2P) (in the early 1980s), or on pseudoephedrine-containing pharmaceuticals, from the mid-2000s. This paper discusses the nitro-aldol reaction occurring between nitroethane and benzaldehyde, which can be utilised in a number of differing routes, in the presence of different bases. The resulting products, namely phenyl-2-nitropropene (P2P pathway) and 2-nitro-1-phenyl-1-propanol (ephedrine pathway) are directly dependant on which base is used; as such, the base may be used to provide an indication of a possible manufacture pathway of methamphetamine at a clandestine laboratory.
History
Journal
Australian journal of forensic sciencesVolume
48Issue
6Pagination
684 - 693Publisher
Taylor & FrancisLocation
Abingdon, Eng.Publisher DOI
ISSN
0045-0618eISSN
1834-562XLanguage
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2016, Australian Academy of Forensic SciencesUsage metrics
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