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Intersections of epigenetics, twinning and developmental asymmetries: insights into monogenic and complex diseases and a role for 3D facial analysis

journal contribution
posted on 2011-08-01, 00:00 authored by Gareth Baynam, Peter Claes, Jeffrey CraigJeffrey Craig, Jack Goldblatt, Stefanie Kung, Peter Le Souef, Mark Walters
For decades the relationships of twinning and alterations in body patterning, such as laterality and asymmetry, have been investigated. However, the tools to define and quantify these relationships have been limited and the majority of these studies have relied on associations with subjectively defined phenotypes. The emerging technologies of 3-dimensional (3D) facial scanning and geometric morphometrics are providing the means to establish objective criteria, including measures of asymmetry, which can be used for phenotypic classification and investigations. Additionally, advances in molecular epigenetics provide new opportunities for novel investigations of mechanisms central to early developmental processes, twinning and related phenotypes. We review the evidence for overlapping etiologies of twinning, asymmetry and selected monogenic and complex diseases, and we suggest that the combination of epigenetic investigations with detailed and objective phenotyping, utilizing 3D facial analysis tools, can reveal insights into the genesis of these phenomena.

History

Journal

Twin research & human genetics

Volume

14

Issue

4

Pagination

305 - 315

Publisher

Cambridge University Press

Location

Oxford, Eng.

ISSN

1832-4274

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2011, Cambridge University Press