enticott-investigatingmirror-2018.pdf (1.1 MB)
Investigating mirror system (MS) activity in adults with ASD when inferring others' intentions using both TMS and EEG
journal contribution
posted on 2018-07-01, 00:00 authored by Eleanor J Cole, Nick E Barraclough, Peter EnticottPeter EnticottASD is associated with mentalizing deficits that may correspond with atypical mirror system (MS) activation. We investigated MS activity in adults with and without ASD when inferring others' intentions using TMS-induced motor evoked potentials (MEPs) and mu suppression measured by EEG. Autistic traits were measured for all participants. Our EEG data show, high levels of autistic traits predicted reduced right mu (8-10 Hz) suppression when mentalizing. Higher left mu (8-10 Hz) suppression was associated with superior mentalizing performances. Eye-tracking and TMS data showed no differences associated with autistic traits. Our data suggest ASD is associated with reduced right MS activity when mentalizing, TMS-induced MEPs and mu suppression measure different aspects of MS functioning and the MS is directly involved in inferring intentions.
History
Journal
Journal of autism and developmental disordersVolume
48Issue
7Pagination
2350 - 2367Publisher
SpringerLocation
New York, N.Y.Publisher DOI
Link to full text
ISSN
0162-3257eISSN
1573-3432Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, The AuthorsUsage metrics
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Keywords
Autism spectrum disorder (ASD)Electroencephalography (EEG)IntentionsMentalizingMirror system (MS)Transcranial magnetic stimulation (TMS)Social SciencesPsychology, DevelopmentalPsychologyAUTISM SPECTRUM DISORDERSTRANSCRANIAL MAGNETIC STIMULATIONHIGH-FUNCTIONING AUTISMNEURON SYSTEMASPERGER-SYNDROMEMU-SUPPRESSIONSINGLE-PULSEQUOTIENT AQCORTICAL UNDERCONNECTIVITYCORTICOSPINAL EXCITABILITYEducation
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