cameron-isgrand-2006.pdf (161.24 kB)
Is grand multiparity associated with an increased risk of dysglycaemia?
journal contribution
posted on 2006-07-01, 00:00 authored by D Simmons, J Shaw, A McKenzie, S Eaton, Adrian CameronAdrian Cameron, P ZimmetAims/hypothesis: We sought to determine the risk of diabetes and IGT/IFG with grand multiparity. Subjects, materials and methods: Women, aged ≥25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]). Results: After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48– 0.84]) and 3 to 4 (OR=0.72 [0.53–0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status. Conclusions/interpretation: Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG.We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.
History
Journal
DiabetologiaVolume
49Issue
7Pagination
1522 - 1527Publisher
Springer-VerlagLocation
[Berlin, Germany]Publisher DOI
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ISSN
0012-186XeISSN
1432-0428Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2006, Springer-VerlagUsage metrics
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