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Localization and expression of selenoprotein S in the testis of Psammomys obesus
journal contribution
posted on 2007-03-01, 00:00 authored by Kelly WindmillKelly Windmill, Janette Tenne-Brown, Richard Bayles, J Trevaskis, Yuan Gao, Ken WalderKen WalderSelenium is an essential trace element and selenoprotein S is a member of the selenoprotein family that has the non-standard amino acid selenocysteine incorporated into the polypeptide. Dietary selenium has been shown to play an important protective role in a number of diseases including cancer, immune function and the male reproductive system. In this study, we have observed high levels of selenoprotein S gene expression in the testis from Psammomys obesus. Real-time PCR and immunofluorescence demonstrate that selenoprotein S expression is low in testes from 4-week-old animals but increases significantly by 8 weeks of age and remains high until 17 weeks of age. Selenoprotein S protein is detected in primary spermatocytes, Leydig and Sertoli cells of 8, 12 and 17-week-old animals. These results suggest that selenoprotein S may play a role in spermatogenesis.
History
Journal
Journal of molecular histologyVolume
38Issue
1Pagination
97 - 101Publisher
Springer NetherlandsLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
1567-2379eISSN
1567-2387Language
engNotes
SpringerLink Date Monday, December 18, 2006Publication classification
C1 Refereed article in a scholarly journalCopyright notice
2006, Springer Science+Business Media B.V.Usage metrics
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