stambas-locationrather-2007.pdf (682.01 kB)
Location rather than CD62L phenotype is critical in the early establishment of influenza-specific T cell memory
journal contribution
posted on 2007-06-01, 00:00 authored by K Kedzierska, John StambasJohn Stambas, M Jenkins, R Keating, S Turner, P DohertyThe rapid recall of influenza virus-specific CD8+ T cell effector function is protective, although our understanding of T cell memory remains incomplete. Recent debate has focused particularly on the CD62L lymph node homing receptor. The present analysis shows that although functional memory can be established from both CD62Lhi and CD62Llo CD8+ T cell subsets soon after initial encounter between naive precursors and antigen, the optimal precursors are CD8+CD44hiCD25lo immune lymphocytes isolated from draining lymph nodes on day 3.5 after influenza virus infection. Analysis of primed T cells at different times after challenge indicates that the capacity to transfer memory is diminished at the peak of the primary cytotoxic T lymphocyte response, challenging speculations that the transition to memory first requires full differentiation to effector status. It seems that location rather than CD62Lhi/lo phenotype may be the more profitable focus for further dissection of the early establishment of T cell memory.
History
Journal
Proceedings of the National Academy of Sciences of the United States of AmericaVolume
104Issue
23Pagination
9782 - 9787Publisher
National Academy of SciencesLocation
Washington, D.C.Publisher DOI
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ISSN
0027-8424eISSN
1091-6490Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2007 by The National Academy of Sciences of the USAUsage metrics
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