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Magnetoencephalography reveals an increased non-target P3a, but not target P3b, that is associated with high non-clinical psychosocial deficits
journal contribution
posted on 2018-01-30, 00:00 authored by Talitha FordTalitha Ford, Will Woods, David P CrewtherAuditory processing deficits are frequently identified in autism and schizophrenia, and the two disorders have been shown to share psychosocial difficulties. This study used magnetoencephalography to investigate auditory processing differences for those with a high degree of a non-clinical autistic and schizotypal trait phenotype, Social Disorganisation (SD). Participants were 18 low (9 female) and 19 high (9 female) SD scorers (18-40 years) who completed a three-stimulus auditory oddball paradigm of speech sounds (standard: 100ms 'o', deviant: 150ms 'o', novel: 150ms 'e'). Spatio-temporal cluster analysis revealed increased amplitude for the high SD group in a left (p = 0.006) and a right (p = 0.020) hemisphere cluster in response to the novel non-target. No cluster differences were found in response to the target deviant. These findings suggest that those with a high degree of the SD phenotype recruit more cortical resources when processing unattended, novel speech stimuli, which may lead to psychosocial deficits.
History
Journal
Psychiatry research: neuroimagingVolume
271Pagination
1 - 7Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
1872-7506Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2017, ElsevierUsage metrics
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Auditory oddballAutismP300SchizotypySocial DisorganisationScience & TechnologyLife Sciences & BiomedicineClinical NeurologyNeuroimagingPsychiatryNeurosciences & NeurologyEVENT-RELATED POTENTIALSSCHIZOTYPAL PERSONALITYMISMATCH NEGATIVITYBRAIN POTENTIALSHIGH-RISK1ST-EPISODE PSYCHOSISASPERGER-SYNDROMEWORKING-MEMORYEEG-DATASCHIZOPHRENIA
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