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Metastasis and the evolution of dispersal
journal contribution
posted on 2019-01-01, 00:00 authored by Tazzio Tissot, François Massol, Beata UjvariBeata Ujvari, Catherine Alix-Panabieres, Nicolas Loeuille, Frédéric ThomasDespite significant progress in oncology, metastasis remains the leading cause of mortality of cancer patients. Understanding the foundations of this phenomenon could help contain or even prevent it. As suggested by many ecologists and cancer biologists, metastasis could be considered through the lens of biological dispersal: the movement of cancer cells from their birth site (the primary tumour) to other habitats where they resume proliferation (metastatic sites). However, whether this model can consistently be applied to the emergence and dynamics of metastasis remains unclear. Here, we provide a broad review of various aspects of the evolution of dispersal in ecosystems. We investigate whether similar ecological and evolutionary principles can be applied to metastasis, and how these processes may shape the spatio-temporal dynamics of disseminating cancer cells. We further discuss complementary hypotheses and propose experimental approaches to test the relevance of the evolutionary ecology of dispersal in studying metastasis.
History
Journal
Proceedings of the Royal Society B: biological sciencesVolume
286Issue
1916Pagination
1 - 9Publisher
The Royal SocietyLocation
London, Eng.Publisher DOI
ISSN
0962-8452eISSN
1471-2954Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, The Author(s)Usage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineBiologyEcologyEvolutionary BiologyLife Sciences & Biomedicine - Other TopicsEnvironmental Sciences & EcologydispersalmetastasiscancerevolutionTUMOR-CELL CLUSTERSBREAST-CANCEREARLY DISSEMINATIONSEED DISPERSALDORMANCYSELECTIONMODELMIGRATIONHETEROGENEITYCOOPERATION
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