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Microfluidic platforms for biomarker analysis

journal contribution
posted on 2014-01-01, 00:00 authored by S Nahavandi, S Baratchi, R Soffe, S Y Tang, Saeid Nahavandi, A Mitchell, K Khoshmanesh
Biomarkers have been described as characteristics, most often molecular, that provide information about biological states, whether normal, pathological, or therapeutically modified. They hold great potential to assist diagnosis and prognosis, monitor disease, and assess therapeutic effectiveness. While a few biomarkers are routinely utilised clinically, these only reflect a very small percentage of all biomarkers discovered. Numerous factors contribute to the slow uptake of these new biomarkers, with challenges faced throughout the biomarker development pipeline. Microfluidics offers two important opportunities to the field of biomarkers: firstly, it can address some of these developmental obstacles, and secondly, it can provide the precise and complex platform required to bridge the gap between biomarker research and the biomarker-based analytical device market. Indeed, adoption of microfluidics has provided a new avenue for advancement, promoting clinical utilisation of both biomarkers and their analytical platforms. This review will discuss biomarkers and outline microfluidic platforms developed for biomarker analysis.

History

Journal

Lab on a chip

Volume

14

Issue

9

Pagination

1496 - 1514

Publisher

RSC Publications

Location

Cambridge, Eng.

eISSN

1473-0189

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2013, RSC Publications