File(s) under permanent embargo
Modified sprouted rice for modulation of curcumin crystallinity and dissolution enhancement by solid dispersion
journal contribution
posted on 2019-01-01, 00:00 authored by T D Luu, B J Lee, Phuong TranPhuong Tran, T T D TranSprouted grains, which is a natural polysaccharide, is the subject of increasing scientific interest due to many benefits for human health. The aim of the present work was to develop sprouted rice (SR) as a safe and useful material for application in dissolution enhancement of anticancer poorly water-soluble drugs such as curcumin by solid dispersions (SDs). SDs were prepared with pure SR and modified sprouted rice (MSR) by the melting method. The dissolution rate, drug crystallinity changes, molecular interactions and wettability were characterized and compared between the formulations. The use of MSR could result in a promising system for improving the dissolution rate of poorly water-soluble drugs. MSR could induce a greater amorphous state and improved wettability of drugs for dissolution enhancement compared to SR. Although both SR and MSR showed hydrogen bonding interaction, insignificant differences between SR and MSR were observed. We found that the crystallinity, interactions and wettability of the drug were significantly affected and modulated by MSR.
History
Journal
Journal of pharmaceutical investigationVolume
49Issue
1Pagination
127 - 134Publisher
SpringerLocation
SingaporePublisher DOI
ISSN
2093-5552eISSN
2093-6214Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, The Korean Society of Pharmaceutical Sciences and TechnologyUsage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC