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Modulation of high fat diet-induced microbiome changes, but not behaviour, by minocycline

journal contribution
posted on 2019-11-01, 00:00 authored by Kyoko Hasebe, Leni RiveraLeni Rivera, Craig SmithCraig Smith, Theodore Allnutt, Tamsyn CrowleyTamsyn Crowley, Tiffanie Nelson, Olivia DeanOlivia Dean, Sean McgeeSean Mcgee, Ken WalderKen Walder, Laura GrayLaura Gray
© 2019 Elsevier Inc. An emerging novel therapeutic agent for major depressive disorder, minocycline, has the potential to influence both gut microbiome and inflammatory status. The present study showed that chronic high fat diet feeding led to changes in both behaviour and the gut microbiome in male mice, without an overt inflammatory response. The diet-induced behavioural changes were characterised as increased immobility in the forced swim test and changes in locomotor activities in the open field test. Minocycline significantly altered the gut microbiome, rendering a community distinctly different to both untreated healthy and diet-affected states. In contrast, minocycline did not reverse high fat diet-induced changes in behaviour.

History

Journal

Brain, behavior, and immunity

Volume

82

Pagination

309 - 318

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0889-1591

eISSN

1090-2139

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Elsevier