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Movement-related potentials in high-functioning autism and Asperger's disorder
journal contribution
posted on 2006-04-01, 00:00 authored by Nicole Rinehart, B J Tonge, J L Bradshaw, R Iansek, Peter EnticottPeter Enticott, K A JohnsonAutism and Asperger's disorder (AD) are neurodevelopmental conditions that affect cognitive and social-communicative function. Using a movement-related potential (MRP) paradigm, we investigated the clinical and neurobiological issue of 'disorder separateness' versus 'disorder variance' in autism and AD. This paradigm has been used to assess basal ganglia/supplementary motor functioning in Parkinson's disease. Three groups (high functioning autism [HFA]: 16 males, 1 female; mean age 12y 5mo [SD 4y 4mo]; AD: 11 males, 2 females; mean age 13y 5mo [SD 3y 8mo]; comparison group: 13 males, 8 females; mean age 13y 10mo [SD 3y 11mo]) completed a cued motor task during electroencephalogram recording of MRPs. The HFA group showed reduced peak amplitude at Cz, indicating less activity over the supplementary motor area during movement preparation. Although an overall significant between-group effect was found for early slope and peak amplitude, sub-analysis revealed that the group with AD did not differ significantly from either group. However, it is suggested that autism and AD may be dissociated on the basis of brain-behaviour correlations of IQ with specific neurobiological measures. The overlap between MRP traces for autism and Parkinson's disease suggests that the neurobiological wiring of motor functioning in autism may bypass the supplementary motor area/primary motor cortex pathway.
History
Journal
Developmental medicine and child neurologyVolume
48Issue
4Pagination
272 - 277Publisher
Wiley-BlackwellLocation
Chichester, Eng.Publisher DOI
ISSN
0012-1622Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2006, Wiley-BlackwellUsage metrics
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No categories selectedKeywords
AdolescentAdultAsperger SyndromeAutistic DisorderChildChild, PreschoolDiagnosis, Computer-AssistedElectroencephalographyEvoked Potentials, MotorFemaleHumansMaleMotor CortexMovement DisordersSocial BehaviorScience & TechnologyLife Sciences & BiomedicineClinical NeurologyPediatricsNeurosciences & NeurologyPARKINSONS-DISEASECHILDHOOD AUTISMMOTOR AREACHILDRENINDIVIDUALSSTRATEGIESCORTEXMODEL
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