kong-multifunctional-2021.pdf (29.17 MB)
Multi-functional core-shell nanofibers for wound healing
journal contribution
posted on 2021-01-01, 00:00 authored by Zhen Li, S Mei, YAJIE DONG, Fenghua SheFenghua She, P Li, Y Li, Lingxue KongLingxue KongCore-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.
History
Journal
NanomaterialsVolume
11Issue
6Article number
1546Pagination
1 - 19Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
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ISSN
2079-4991eISSN
2079-4991Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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co-axial centrifugal spinningcore-shell nanofiberdrug deliverywound healingScience & TechnologyPhysical SciencesTechnologyChemistry, MultidisciplinaryNanoscience & NanotechnologyMaterials Science, MultidisciplinaryPhysics, AppliedChemistryScience & Technology - Other TopicsMaterials SciencePhysicsIN-VIVOCONTROLLED-RELEASEGROWTH-FACTORELECTROSPUN NANOFIBERSEXTRACELLULAR-MATRIXPOLYMER NANOFIBERSHIGH-THROUGHPUTCHITOSANSCAFFOLDSMORPHOLOGY
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