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Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers
journal contribution
posted on 2013-12-01, 00:00 authored by Swati Dawar, Neha Singh, Rupinder Kanwar, Lee KennedyLee Kennedy, R Veedu, S Zhou, S Krishnakumar, S Hazra, S Sasidharan, Wei DuanWei Duan, Jagat KanwarThe recurrence and metastatic spread of cancer are major drawbacks in cancer treatment. Although chemotherapy is one of the most effective methods for the treatment of metastatic cancers, it is nonspecific and causes significant toxic damage. The development of drug resistance to chemotherapeutic agents through various mechanisms also limits their therapeutic potential. However, as we discuss here, the use of nanodelivery systems that are a combination of diagnostics and therapeutics (theranostics) is as relatively novel concept in the treatment of cancer. Such systems are likely to improve the therapeutic benefits of encapsulated drugs and can transit to the desired site, maintaining their pharmaceutical properties. The specific targeting of malignant cells using multifunctional nanoparticles exploits theranostics as an improved agent for delivering anticancer drugs and as a new solution for overriding drug resistance.
History
Journal
Drug discovery todayVolume
18Issue
23-24Pagination
1292 - 1300Publisher
ElsevierLocation
London, EnglandPublisher DOI
ISSN
1359-6446eISSN
1878-5832Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2013, ElsevierUsage metrics
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No categories selectedKeywords
metastatic spread of cancermetastatic cancerschemotherapytoxic damagedrug resistanceencapsulated drugsnanodelivery systemsmultifunctional nanoparticlesScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyPOLY(BETA-AMINO ESTER) NANOPARTICLESMESOPOROUS SILICA NANOPARTICLESTUMOR-TARGETED DELIVERYPH-SENSITIVE SYSTEMMULTIDRUG-RESISTANCEHYDROPHOBIC DRUGSGLYCOPROTEINDOXORUBICINEFFICACYTRANSPORTERS
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