dean-nacetylcysteine-2015.pdf (6.43 MB)
N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review
journal contribution
posted on 2015-04-30, 00:00 authored by G Oliver, Olivia DeanOlivia Dean, D Camfield, S Blair-West, C Ng, Michael BerkMichael Berk, J SarrisOBJECTIVE: Obsessive compulsive and related disorders are a collection of debilitating psychiatric disorders in which the role of glutamate dysfunction in the underpinning neurobiology is becoming well established. N-acetyl cysteine (NAC) is a glutamate modulator with promising therapeutic effect. This paper presents a systematic review of clinical trials and case reports exploring the use of NAC for these disorders. A further objective was to detail the methodology of current clinical trials being conducted in the area. METHODS: PubMed, Web of Science and Cochrane Library Database were searched for human clinical trials or case reports investigating NAC in the treatment of obsessive compulsive disorder (OCD) or obsessive compulsive related disorders. Researchers with known involvement in NAC studies were contacted for any unpublished data. RESULTS: Four clinical trials and five case reports/series were identified. Study durations were commonly 12-weeks, using 2,400-3,000 mg/day of NAC. Overall, NAC demonstrates activity in reducing the severity of symptoms, with a good tolerability profile and minimal adverse effects. Currently there are three ongoing randomized controlled trials using NAC for OCD (two adults and one pediatric), and one for excoriation. CONCLUSIONS: Encouraging results have been demonstrated from the few pilot studies that have been conducted. These results are detailed, in addition to a discussion of future potential research.
History
Journal
Clinical psychopharmacology and neuroscienceVolume
13Issue
1Pagination
12 - 24Publisher
Korean College of NeuropsychopharmacologyLocation
Korea (South)Publisher DOI
ISSN
1738-1088eISSN
2093-4327Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, Korean College of NeuropsychopharmacologyUsage metrics
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No categories selectedKeywords
GlutamateObsessive-compulsive disorderReviewTrichotillomaniaacetylcysteinesystematicScience & TechnologyLife Sciences & BiomedicineNeurosciencesPharmacology & PharmacyNeurosciences & NeurologyTrichotillomania, acetylcysteineReview, systematicPRADER-WILLI-SYNDROMEMAGNETIC-RESONANCE-SPECTROSCOPYANTERIOR CINGULATE CORTEXHAIR PULLING DISORDERDOUBLE-BLINDNUCLEUS-ACCUMBENSSKIN-PICKINGACETYLCYSTEINE AUGMENTATIONPEDIATRIC TRICHOTILLOMANIAGLUTAMATERGIC DYSFUNCTION
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