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Neurocircuitry of fear extinction in adult and juvenile rats
journal contribution
posted on 2018-10-01, 00:00 authored by D E Ganella, L D Nguyen, L Lee-Kardashyan, L E Kim, A G Paolini, Jee Hyun KimJee Hyun KimIn contrast to adult rodents, juvenile rodents fail to show relapse following extinction of conditioned fear. Using different retrograde tracers injected into the infralimbic cortex (IL) and the ventral hippocampus (vHPC) in conjunction with c-Fos and parvalbumin (PV) immunochemistry, we investigated the neurocircuitry of extinction in juvenile and adult rats. Regardless of fear extinction or retrieval, juvenile rats had more c-Fos+ neurons in the basolateral amygdala (BLA) compared to adults, and showed a higher proportion of c-Fos+ IL-projecting neurons. Adult rats had more activated vHPC-projecting BLA neurons following extinction compared to retrieval, a difference not observed in juvenile rats. The number of activated vHPC- or IL-projecting BLA neurons was significantly correlated with freezing levels in adult, but not juvenile, rats. We also identified activated neurons in the BLA that simultaneously project to the IL and vHPC in the retrieval groups at both ages. This study provides novel insight into the neural process underlying extinction, especially in the juvenile period.
History
Journal
Behavioural Brain ResearchVolume
351Pagination
161 - 167Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0166-4328eISSN
1872-7549Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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