shigdar-noninvasive-2020.pdf (709.39 kB)
Non-invasive delivery of therapeutics into the brain: The potential of aptamers for targeted delivery
journal contribution
posted on 2020-01-01, 00:00 authored by B Bukari, Rasika SamarasingheRasika Samarasinghe, J Noibanchong, Sarah ShigdarSarah ShigdarThe blood-brain barrier (BBB) is a highly specialised network of blood vessels that effectively separates the brain environment from the circulatory system. While there are benefits, in terms of keeping pathogens from entering the brain, the BBB also complicates treatments of brain pathologies by preventing efficient delivery of macromolecular drugs to diseased brain tissue. Although current non-invasive strategies of therapeutics delivery into the brain, such as focused ultrasound and nanoparticle-mediated delivery have shown various levels of successes, they still come with risks and limitations. This review discusses the current approaches of therapeutic delivery into the brain, with a specific focus on non-invasive methods. It also discusses the potential for aptamers as alternative delivery systems and several reported aptamers with promising preliminary results.
History
Journal
BiomedicinesVolume
8Issue
5Article number
120Pagination
1 - 20Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
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ISSN
2227-9059eISSN
2227-9059Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Science & TechnologyLife Sciences & BiomedicineMedicine, Research & ExperimentalPharmacology & PharmacyResearch & Experimental Medicineantibodyaptamerblood-brain barrierbrain pathologydrug deliverynon-invasiveSELEXCELL ADHESION MOLECULEPHASE-II TRIALDRUG-DELIVERYHIGH-AFFINITYTRANSFERRIN RECEPTORMONOCLONAL-ANTIBODYFOCUSED ULTRASOUNDBARRIER DISRUPTIONBREAST-CANCERRNA APTAMERBiochemistry & Molecular Biologyantibody, aptamer, blood-brain barrier, brain pathology, drug delivery, non-invasive, SELEX
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