shigdar-noveldetectionof-2020.pdf (1.02 MB)
Novel detection of nasty bugs, prevention is better than cure
journal contribution
posted on 2021-01-01, 00:00 authored by M Strom, Tamsyn CrowleyTamsyn Crowley, Sarah ShigdarSarah ShigdarHospital-acquired infections (HAIs) are a growing concern around the world. They contribute to increasing mortality and morbidity rates and are an economic threat. All hospital patients have the potential to contract an HAI, but those with weakened or inferior immune systems are at highest risk. Most hospital patients will contract at least one HAI, but many will contract multiple ones. Bacteria are the most common cause of HAIs and contribute to 80–90% of all HAIs, with Staphylococcus aureus, Clostridium difficile, Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae accounting for the majority. Each of these bacteria are highly resistant to antibiotics and can produce a protective film, known as a biofilm, to further prevent their eradication. It has been shown that by detecting and eradicating bacteria in the environment, infection rates can be reduced. The current methods for detecting bacteria are time consuming, non-specific, and prone to false negatives or false positives. Aptamer-based biosensors have demonstrated specific, time-efficient and simple detection, highlighting the likelihood that they could be used in a similar way to detect HAI-causing bacteria.
History
Journal
International journal of molecular sciencesVolume
22Issue
1Article number
149Pagination
1 - 19Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
Link to full text
ISSN
1661-6596eISSN
1422-0067Language
EnglishPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Keywords
Science & TechnologyLife Sciences & BiomedicinePhysical SciencesBiochemistry & Molecular BiologyChemistry, MultidisciplinaryChemistryaptamersdetection systemshospital-acquired infectionsRESISTANT STAPHYLOCOCCUS-AUREUSCARE-ASSOCIATED INFECTIONSLABEL-FREE DETECTIONGRAM-NEGATIVE BACTERIADNA APTAMERS BINDINGLATERAL FLOW ASSAYLENGTH-OF-STAYKLEBSIELLA-PNEUMONIAENOSOCOMIAL INFECTIONSGenetics
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