Deakin University
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Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine

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journal contribution
posted on 2015-01-01, 00:00 authored by Dongxi Xiang, Sarah ShigdarSarah Shigdar, G Qiao, Tao Wang, Abbas KouzaniAbbas Kouzani, S F Zhou, Lingxue KongLingxue Kong, Y Li, C Pu, Wei DuanWei Duan
Conventional anticancer therapies, such as chemo- and/or radio-therapy are often unable to completely eradicate cancers due to abnormal tumor microenvironment, as well as increased drug/radiation resistance. More effective therapeutic strategies for overcoming these obstacles are urgently in demand. Aptamers, as chemical antibodies that bind to targets with high affinity and specificity, are a promising new and novel agent for both cancer diagnostic and therapeutic applications. Aptamer-based cancer cell targeting facilitates the development of active targeting in which aptamer-mediated drug delivery could provide promising anticancer outcomes. This review is to update the current progress of aptamer-based cancer diagnosis and aptamer-mediated active targeting for cancer therapy in vivo, exploring the potential of this novel form of targeted cancer therapy.

History

Journal

Theranostics

Volume

5

Issue

1

Pagination

23 - 42

Publisher

Ivyspring International

Location

Wyoming, N.S.W.

ISSN

1838-7640

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2015, Ivyspring International