xiang-nucleicacidaptamer-2015.pdf (17.24 MB)
Nucleic acid aptamer-guided cancer therapeutics and diagnostics: the next generation of cancer medicine
journal contribution
posted on 2015-01-01, 00:00 authored by Dongxi Xiang, Sarah ShigdarSarah Shigdar, G Qiao, Tao Wang, Abbas KouzaniAbbas Kouzani, S F Zhou, Lingxue KongLingxue Kong, Y Li, C Pu, Wei DuanWei DuanConventional anticancer therapies, such as chemo- and/or radio-therapy are often unable to completely eradicate cancers due to abnormal tumor microenvironment, as well as increased drug/radiation resistance. More effective therapeutic strategies for overcoming these obstacles are urgently in demand. Aptamers, as chemical antibodies that bind to targets with high affinity and specificity, are a promising new and novel agent for both cancer diagnostic and therapeutic applications. Aptamer-based cancer cell targeting facilitates the development of active targeting in which aptamer-mediated drug delivery could provide promising anticancer outcomes. This review is to update the current progress of aptamer-based cancer diagnosis and aptamer-mediated active targeting for cancer therapy in vivo, exploring the potential of this novel form of targeted cancer therapy.
History
Journal
TheranosticsVolume
5Issue
1Pagination
23 - 42Publisher
Ivyspring InternationalLocation
Wyoming, N.S.W.Publisher DOI
ISSN
1838-7640Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, Ivyspring InternationalUsage metrics
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No categories selectedKeywords
active targeting aptamer cancer stem cell cancer theranostic cancer therapy chemoresistanceScience & TechnologyLife Sciences & BiomedicineMedicine, Research & ExperimentalResearch & Experimental Medicineaptamercancer therapyactive targetingcancer stem cellchemoresistancecancer theranosticCELL ADHESION MOLECULEMESOPOROUS SILICA NANOPARTICLESINTERSTITIAL FLUID PRESSUREENDOTHELIAL GROWTH-FACTORSPONTANEOUS ANIMAL TUMORSOVARIAN-CARCINOMA CELLSTARGETED DRUG-DELIVERYSTEM-CELLSIN-VIVOBREAST-CANCER
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