ashton-nutraceuticalsandnutritional-2019.pdf (262.58 kB)
Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review
journal contribution
posted on 2019-04-01, 00:00 authored by Melanie AshtonMelanie Ashton, Michael BerkMichael Berk, Chee H Ng, Malcolm Hopwood, Bianca KavanaghBianca Kavanagh, Lana WilliamsLana Williams, Jerome Sarris, Olivia DeanOlivia DeanINTRODUCTION: First line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research question: in patients with BD, how does use of nutraceutical treatments compare with placebo in reducing depressive and mania symptoms? METHODS AND ANALYSIS: Clinical trials will be identified through database searches using PubMed via PubMed, EMBASE via embase.com, Cochrane Central Register of Controlled Clinical Trials (CENTRAL) via cochranelibrary.com and CINAHL Complete via EBSCO. Search terms for BD and specific nutraceuticals (75 total search terms) will be used. Double-blind, randomised, controlled, clinical trials of adults with BD will be included in the review. Risk of bias will be assessed using the Cochrane Collaboration's tool for assessing risk of bias in randomised trials. ETHICS AND DISSEMINATION: This review will only look at published data (already reviewed for ethical compliance); therefore, ethical approval is not required. We aim to publish the systematic review in a peer-reviewed journal and present at conferences. PROSPERO REGISTRATION NUMBER: CRD42019100745.
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Journal
BMJ OpenVolume
9Issue
4Article number
e025640Publisher
BMJ Publishing GroupLocation
London, Eng.Publisher DOI
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eISSN
2044-6055Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, The AuthorsUsage metrics
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