ujvari-oncogenesisasa-2018.pdf (327.74 kB)
Oncogenesis as a selective force: adaptive evolution in the face of a transmissible cancer
journal contribution
posted on 2018-03-01, 00:00 authored by T Russell, Thomas MadsenThomas Madsen, F Thomas, Nynke RavenNynke Raven, R Hamede, Beata UjvariBeata UjvariSimilar to parasites, malignant cells exploit the host for energy, resources and protection, thereby impairing host health and fitness. Although cancer is widespread in the animal kingdom, its impact on life history traits and strategies have rarely been documented. Devil facial tumour disease (DFTD), a transmissible cancer, afflicting Tasmanian devils (Sarcophilus harrisii), provides an ideal model system to monitor the impact of cancer on host life-history, and to elucidate the evolutionary arms-race between malignant cells and their hosts. Here we provide an overview of parasite-induced host life history (LH) adaptations, then both phenotypic plasticity of LH responses and changes in allele frequencies that affect LH traits of Tasmanian devils in response to DFTD are discussed. We conclude that akin to parasites, cancer can directly and indirectly affect devil LH traits and trigger host evolutionary responses. Consequently, it is important to consider oncogenic processes as a selective force in wildlife.
History
Journal
BioessaysVolume
40Issue
3Article number
1700146Pagination
1 - 9Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
ISSN
0265-9247eISSN
1521-1878Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2018, WILEY Periodicals, Inc.Usage metrics
Keywords
Tasmanian deviladaptationcancer immunotherapydevil facial tumour diseaseevolutionary arms-racelife history traitsreproductive strategiesScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyBiologyLife Sciences & Biomedicine - Other TopicsFACIAL-TUMOR DISEASELIFE-HISTORY TRAITSDEVILS SARCOPHILUS-HARRISIIGENETIC DIVERSITYREPRODUCTIVE EFFORTPOPULATION DECLINESUPPRESSOR GENECOMMON LIZARDTICK LOADEvolutionary Biology
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