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Oral zinc sulfate solutions inhibit sweet taste perception
journal contribution
posted on 2004-01-01, 00:00 authored by Russell KeastRussell Keast, T Canty, P BreslinWe investigated the ability of zinc sulfate (5, 25, 50 mM) to inhibit the sweetness of 12 chemically diverse sweeteners, which were all intensity matched to 300 mM sucrose [800 mM glucose, 475 mM fructose, 3.25 mM aspartame, 3.5 mM saccharin, 12 mM sodium cyclamate, 14 mM acesulfame-K, 1.04 M sorbitol, 0.629 mM sucralose, 0.375 mM neohesperidin dihydrochalcone (NHDC), 1.5 mM stevioside and 0.0163 mM thaumatin]. Zinc sulfate inhibited the sweetness of most compounds in a concentration dependent manner, peaking with 80% inhibition by 50 mM. Curiously, zinc sulfate never inhibited the sweetness of Na-cyclamate. This suggests that Na-cyclamate may access a sweet taste mechanism that is different from the other sweeteners, which were inhibited uniformly (except thaumatin) at every concentration of zinc sulfate. We hypothesize that this set of compounds either accesses a single receptor or multiple receptors that are inhibited equally by zinc sulfate at each concentration.
History
Journal
Chemical sensesVolume
29Issue
6Pagination
513 - 521Publisher
Oxford University PressLocation
Oxford, EnglandPublisher DOI
ISSN
0379-864XeISSN
1464-3553Language
engNotes
This is a pre-copy-editing, author-produced PDF of an article accepted for publication by Chemical senses following peer review. The definitive publisher-authenticated version Keast, Russell, Canty, Thomas M. and Breslin, Paul A. S. 2004, Oral zinc sulfate solutions inhibit sweet taste perception, Chemical senses, vol. 29, no. 6, pp. 513-521. is available online at http://dx.doi.org/10.1093/chemse/bjh053Publication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2004, Oxford University PressUsage metrics
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cyclamatezincsweet taste inhibitionhuman psychophysicsScience & TechnologyLife Sciences & BiomedicineBehavioral SciencesFood Science & TechnologyNeurosciencesPhysiologyNeurosciences & NeurologyCROSS-ADAPTATIONRECEPTOR MECHANISMSMAMMALIAN SWEETNERVE RESPONSESUMAMI TASTEMIXTURESINDIVIDUALSINTENSITYMAGNITUDESYNERGISM
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