vijayakumar-orbitofrontalsulcogyral-2014.pdf (355.41 kB)
Orbitofrontal sulcogyral patterns are related to temperamental risk for psychopathology
journal contribution
posted on 2014-02-01, 00:00 authored by S Whittle, C Bartholomeusz, M Yücel, M Dennison, Nandi VijayakumarNandi Vijayakumar, N B AllenThere are marked individual differences in the pattern of cortical (sulcogyral) folding in the orbitofrontal cortex (OFC), and there is a growing literature suggesting that these individual differences are associated with risk for psychotic disorders. To date, however, no study has investigated whether OFC folding patterns are associated with broader risk factors relevant to a range of psychopathology. This study helps address this knowledge gap by examining whether OFC sulcogyral folding patterns are associated with putative risk factors, specifically affective temperament and psychiatric symptoms, in a large community sample (N = 152) of adolescents. Results showed that the most common pattern of folding ('Type I', marked by discontinuity of the medial orbital sulcus and continuity of the lateral orbital sulcus) was associated with low levels of Surgency, high levels of Negative Affectivity (in girls) and higher depressive symptoms. This pattern was also associated with reduced thickness of OFC gray matter. Overall, the findings, combined with previous work, suggest some specificity of neurodevelopmental risk for different types of psychopathology. Thus, these results have the potential to inform the early identification of at-risk individuals. © The Author (2012).
History
Journal
Social cognitive and affective neuroscienceVolume
9Issue
2Pagination
232 - 239Publisher
Oxford University PressLocation
Oxford, Eng.Publisher DOI
Link to full text
ISSN
1749-5024eISSN
1749-5024Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2012, The AuthorsUsage metrics
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Science & TechnologySocial SciencesLife Sciences & BiomedicineNeurosciencesPsychologyPsychology, ExperimentalNeurosciences & Neurologygyrificationtemperamentorbitofrontal cortexriskadolescenceOBSESSIVE-COMPULSIVE DISORDERBRAIN SEGMENTATIONVOLUME REDUCTIONSEX-DIFFERENCESCORTEXSCHIZOPHRENIAEMOTIONANXIETYMRITHICKNESS
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