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Parkinson’s disease is accompanied by intertwined alterations in iron metabolism and activated immune-inflammatory and oxidative stress pathways
journal contribution
posted on 2017-05-01, 00:00 authored by C C de Farias, M Maes, K L Bonifácio, A K Matsumoto, Chiara Bortolasci, A D S Nogueira, F F Brinholi, H K Morimoto, L B de Melo, E G Moreira, D S BarbosaBackground: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a complex interplay between peripheral and central inflammatory and oxidative stress pathways. Objective: To investigate immune-inflammatory and oxidative stress pathways in relation to iron metabolism in peripheral blood of PD patients and healthy controls. Method: We recruited 56 healthy individuals and 56 PD patients in stages 1-3 of Hoehn and Yahr Scale. Plasma haptoglobin (Hp), homocysteine, interleukin 6, soluble interleukin 6 receptor, iron (Fe), ferritin, total iron binding capacity, transferrin (Tf), soluble transferrin receptor (sTfR), malondialdehyde (MDA) and paraoxonase 1 (PON1) were measured. Results: PD was associated with significant changes in Tf (lowered), sTfR, ferritin, Hp, interleukin 6 and MDA (all increased) levels, while there was a trend towards a negative association with PON1. Logistic regression showed that the most significant biomarkers of PD were MDA, sTfR, Hp and ferritin. Moreover, Fe levels were negatively associated with Hp and positively with PON1, total iron binding capacity and Tf, while ferritin and sTfR were positively associated with MDA levels. Conclusion: Our study indicates a state of systemic inflammation and oxidative stress in PD patients coupled with alterations in Fe metabolism. Chronic inflammation and oxidative pathways in PD may in part determine changes in iron metabolism. New drug treatments for PD should target inflammatory and oxidative stress pathways and iron metabolism as well.
History
Journal
CNS and neurological disorders - drug targetsVolume
16Issue
4Pagination
484 - 491Publisher
Bentham Science PublishersLocation
Beijing, ChinaPublisher DOI
ISSN
1871-5273eISSN
1996-3181Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
[2017, Bentham Science Publishers]Usage metrics
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No categories selectedKeywords
inflammationiron metabolismoxidative stressParkinson's diseaseperipheral biomarkerssystemic diseaseScience & TechnologyLife Sciences & BiomedicineNeurosciencesPharmacology & PharmacyNeurosciences & NeurologySERUM-LEVELSHAPTOGLOBIN PHENOTYPEHOMOCYSTEINE LEVELSPARAOXONASEBIOMARKERSIL-6INTERLEUKIN-6ASSOCIATIONCYTOKINESFERRITIN
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