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Participant characteristics as modifiers of response to N-Acetyl cysteine (NAC) in obsessive-compulsive disorder

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journal contribution
posted on 2016-01-01, 00:00 authored by J Sarris, G Oliver, D A Camfield, Olivia DeanOlivia Dean
We previously reported on a 16-week, double-blind, randomized placebo-controlled trial (RCT) using 3 grams per day of N-acetyl cysteine (NAC) (1.5 grams twice per day) in 44 participants (aged 18–70) with DSM-5-diagnosed obsessive-compulsive disorder (OCD). We now report on an analysis of age, severity and duration of illness, OCD presentation type, baseline anxiety and depression scores, as well as the use of antidepressant medications as potentially modifying factors. Results revealed a significant effect (p =.037) for younger participants (under mean age of 34) responding to NAC. This remained significant using OCD severity as a covariate (p =.044). For those under 34 years of age with less than 17 years of OCD duration, this was also significant (p =.037). Regression analysis within the NAC treatment group also revealed that duration of OCD presentation was a significant predictor of Yale-Brown Obsessive Compulsive Scale (YBOCS) change at study endpoint (p =.019), whereas baseline Montgomery–Asberg Depression Rating Scale scores were also a trend-level predictor (p =.060) of YBOCS change in the NAC group.

History

Journal

Clinical psychological science

Volume

4

Issue

6

Pagination

1104 - 1111

Publisher

Sage Publications

Location

London, Eng.

ISSN

2167-7026

eISSN

2167-7034

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2016, The Authors