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Perspectives on strategies using swellable polymers in solid dispersions for controlled drug release
Poorly water-soluble drugs, which commonly face the issue of poor absorption and low bioavailability, have been under ongoing research of many formulation scientists for the past few decades. Solid dispersion is one of the most effective strategies in concerns for improving bioavailability of poorly water-soluble drugs. Either application of solid dispersions in dissolution enhancement of poorly water-soluble drugs or the use of swellable polymers in controlled drug release has been reported in pharmaceutical designs widely. However, a review of strategies of using swellable polymers in solid dispersion to take a full advantage of these polymers as a current perspective in facilitating drug bioavailability enhancement is still missing. In this review, we aim to provide a summary of techniques used to formulate a swellable polymer in solid dispersion especially a description of a suitable fabrication method in design of a controlled release solid dispersion.
History
Journal
Current pharmaceutical designVolume
23Issue
11Pagination
1639 - 1648Publisher
Bentham Science PublishersLocation
Beijing, ChinaPublisher DOI
ISSN
1381-6128eISSN
1873-4286Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2017, [Bentham Science Publishers]Usage metrics
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No categories selectedKeywords
Solid dispersionbioavailabilitycontrolled releasedissolution ratepoor absorptionpoorly water-soluble drugsswellable polymersScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyWATER-SOLUBLE DRUGSHOT-MELT EXTRUSIONBIOPHARMACEUTICS CLASSIFICATION-SYSTEMSODIUM CARBOXYMETHYL CELLULOSECARBOXYVINYLPOLYMER INTERPOLYMER COMPLEXLIPID-BASED FORMULATIONSSPRAY-DRYING PROCESSHYDROXYPROPYL METHYLCELLULOSEPOLY(ETHYLENE OXIDE)POLYETHYLENE OXIDEpoor\nabsorption
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