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Phosphatase and feedback regulation of Raf-1 signaling

journal contribution
posted on 2007-01-01, 00:00 authored by Amardeep DhillonAmardeep Dhillon, A Von Kriegsheim, J Grindlay, W Kolch
The Raf-1 kinase is an effector of Ras GTPases that lies at the apex of the three-tier Raf/MEK/ERK pathway. Raf-1 activation is a complex process that entails two major events - relief of autoinhibition imposed by the regulatory domain and kinase domain activation. Recent studies indicate that the transition of Raf-1 from an active to an inactive state bears similar complexity to the activation process. Both these events require dynamic changes in Raf-1 phosphorylation. Here, we discuss the critical role of phosphatases and feedback phosphorylation during activation and inactivation of Raf-1 signaling. ©2007 Landes Bioscience.

History

Journal

Cell Cycle

Volume

6

Issue

1

Pagination

3 - 7

ISSN

1538-4101

eISSN

1551-4005

Publication classification

C1.1 Refereed article in a scholarly journal