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Polymer conjugate-based nanomaterials for drug delivery
journal contribution
posted on 2014-01-01, 00:00 authored by Phuong TranPhuong Tran, T T-D Tran, T V VoThe structure of polymeric amphiphiles with both hydrophilic and hydrophobic groups forming self-assembled nanoparticles have attracted increasing attention in studies of delivery systems of therapeutic agents. An amphiphilic carrier for self-assembly in an aqueous solution is preferable because of its structure with a hydrophobic core and hydrophilic outer shell, which can be applied to many biotechnological and pharmaceutical fields with numerous types of drugs. An amphiphilic carrier for self-assembly also represents the most appealing delivery system owing to its exceptional advantages in selectively delivering drugs to tumor cells and thus, reduction of side effects. This paper reviews two types of self-assembled nanoparticles/micelles of conjugated polymeric amphiphiles: (1) self-assembled micelles/nanoparticles of amphiphilic conjugates followed by drug loading and (2) self-assembled micelles/nanoparticles of polymer-drug conjugates where a conjugation reaction occurs between the polymer and drug. The development of the research has been addressed in this review with up-to-date references. In conclusion, the challenges and remaining difficulties for the future development are discussed.
History
Journal
Journal of nanoscience and nanotechnologyVolume
14Issue
1Pagination
815 - 827Publisher
American Scientific PublishersLocation
Valencia, Calif.Publisher DOI
ISSN
1533-4880Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2014, American Scientific PublishersUsage metrics
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No categories selectedKeywords
AbsorptionCrystallizationDelayed-Action PreparationsDrug CompoundingHydrophobic and Hydrophilic InteractionsNanocapsulesParticle SizePolymersSurface PropertiesScience & TechnologyPhysical SciencesTechnologyChemistry, MultidisciplinaryNanoscience & NanotechnologyMaterials Science, MultidisciplinaryPhysics, AppliedPhysics, Condensed MatterChemistryScience & Technology - Other TopicsMaterials SciencePhysicsDrug DeliveryPolymer ConjugatesPolymer-Drug ConjugatesSelf-Assembled NanoparticlesBLOCK-COPOLYMER MICELLESSELF-AGGREGATED NANOPARTICLESIN-VITROMAGNETIC NANOPARTICLESCANCER-CHEMOTHERAPYCONTRAST AGENTSIDE-CHAINSPHASE-IN-(2-HYDROXYPROPYL)METHACRYLAMIDE COPOLYMERSPACLITAXEL BIOAVAILABILITY
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