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Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies
journal contribution
posted on 2018-01-01, 00:00 authored by David SkvarcDavid Skvarc, Michael BerkMichael Berk, Linda Byrne, Olivia DeanOlivia Dean, Seetal DoddSeetal Dodd, Matthew Lewis, Drew MarriottDrew Marriott, Eileen Moore, G Morris, Richard PageRichard Page, Laura GrayLaura GrayPost-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with significant clinical, social and financial impacts for patients and their communities. The underlying pathophysiology is becoming increasingly understood, with the role of neuroinflammation and oxidative stress secondary to surgery and anaesthesia strongly implicated. This review aims to describe the putative mechanisms by which surgery-induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways.
History
Journal
Neuroscience and biobehavioral reviewsVolume
84Pagination
116 - 133Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0149-7634eISSN
1873-7528Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, Elsevier LtdUsage metrics
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No categories selectedKeywords
BiomarkersCognitionNeuroinflammationOxidative stressPost-operative cognitive dysfunctionScience & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyCENTRAL-NERVOUS-SYSTEMN-ACETYL-CYSTEINETRAUMATIC BRAIN-INJURYPREOPERATIVE STATIN THERAPYCEREBROSPINAL-FLUID MARKERSAPOLIPOPROTEIN-E GENOTYPELONG-TERM POTENTIATIONNITRIC-OXIDE PRODUCTSBYPASS GRAFT-SURGERYMOBILITY GROUP BOX-1
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