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Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies

journal contribution
posted on 2018-01-01, 00:00 authored by David SkvarcDavid Skvarc, Michael BerkMichael Berk, Linda Byrne, Olivia DeanOlivia Dean, Seetal DoddSeetal Dodd, Matthew Lewis, Drew MarriottDrew Marriott, Eileen Moore, G Morris, Richard PageRichard Page, Laura GrayLaura Gray
Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with significant clinical, social and financial impacts for patients and their communities. The underlying pathophysiology is becoming increasingly understood, with the role of neuroinflammation and oxidative stress secondary to surgery and anaesthesia strongly implicated. This review aims to describe the putative mechanisms by which surgery-induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways.

History

Journal

Neuroscience and biobehavioral reviews

Volume

84

Pagination

116 - 133

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0149-7634

eISSN

1873-7528

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, Elsevier Ltd