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Preliminary results of the application of a silk fibroin scaffold to otology
journal contribution
posted on 2010-03-01, 00:00 authored by B Levin, S Redmond, Rangam RajkhowaRangam Rajkhowa, R Eikelboom, R Marano, M AtlasThe surgical treatment to repair chronic tympanic membrane perforations is myringoplasty. Although multiple autologous grafts, allografts, and synthetic graft materials have been used over the years, no single graft material is superior for repairing all perforation types. Recently, the remarkable properties of silk fibroin protein have been studied, with biomedical and tissue engineering applications in mind, across a number of medical and surgical disciplines. The present study examines the use of silk fibroin for its potential suitability as an alternative graft in myringoplasty surgery by investigating the growth and proliferation of human tympanic membrane keratinocytes on a silk fibroin scaffold in vitro. Light microscopy, immunofluorescent staining, and confocal imaging all reveal promising preliminary results. The biocompatibility, transparency, stability, high tensile strength, and biodegradability of fibroin make this biomaterial an attractive option to study for this utility.
History
Journal
Otolaryngology–head and neck surgeryVolume
142Issue
3Season
Supplement 1Publisher
Mosby, Inc.Location
Philadelphia, Pa.Publisher DOI
ISSN
0194-5998eISSN
1097-6817Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2010, American Academy of Otolaryngology–Head and Neck Surgery Foundation. All rights reserved.Usage metrics
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