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Preparation of nanoparticles by crosslinking folate conjugated chitosan with vanillin and its characterization
journal contribution
posted on 2012-01-01, 00:00 authored by M Zhou, Puwang Li, Guang Wang, Z Yang, Zheng Peng, Lingxue KongLingxue KongFunctionalized chitosan (CS) were widely used as drug delivery system in the chemotherapy of various disease. In this work, folate (FA) was conjugated into chitosan molecular as targeting ligand based on Schiff reaction between –NH2 group of CS and –COOH group of FA. And nanoparticles were made by emulsion method with vanillin novel cross-linking agent. The FA modified CS and its nanoparticles were characterized by Fourier transform spectroscopy (FT-IR), scanning electron microscope (SEM) and Zeta potential. SEM results confirmed the nanoparticles made from FA-CS conjugate were spherical in shape and were about 100 nm in size. Zeta potential analysis revealed that the nanoparticles were negatively charged with charge density of -7.73mV.
History
Journal
Applied mechanics and materialsVolume
466-467Pagination
454 - 457Publisher
Trans Tech PublicationsLocation
Stafa-Zurich, SwitzerlandISSN
1660-9336eISSN
1662-7482Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2012, Trans Tech Publications, SwitzerlandUsage metrics
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