olsson-prospectsforepigenetic-2009.pdf (545.25 kB)
Prospects for epigenetic epidemiology
journal contribution
posted on 2009-02-15, 00:00 authored by D Foley, Jeffrey CraigJeffrey Craig, R Morley, Craig OlssonCraig Olsson, T Dwyer, K Smith, R SafferyEpigenetic modification can mediate environmental influences on gene expression and can modulate the disease risk associated with genetic variation. Epigenetic analysis therefore holds substantial promise for identifying mechanisms through which genetic and environmental factors jointly contribute to disease risk. The spatial and temporal variance in epigenetic profile is of particular relevance for developmental epidemiology and the study of aging, including the variable age at onset for many common diseases. This review serves as a general introduction to the topic by describing epigenetic mechanisms, with a focus on DNA methylation; genetic and environmental factors that influence DNA methylation; epigenetic influences on development, aging, and disease; and current methodology for measuring epigenetic profile. Methodological considerations for epidemiologic studies that seek to include epigenetic analysis are also discussed.
History
Journal
American journal of epidemiologyVolume
169Issue
4Pagination
389 - 400Publisher
Oxford University PressLocation
Cary, NCPublisher DOI
Link to full text
ISSN
0002-9262eISSN
1476-6256Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2009, The AuthorsUsage metrics
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DNA methylationenvironmentepigenesisgeneticfolic acidScience & TechnologyLife Sciences & BiomedicinePublic, Environmental & Occupational HealthMESSENGER-RNA EXPRESSIONGENOMIC DNA HYPERMETHYLATIONDIETARY-PROTEIN RESTRICTIONALPHA SYNUCLEIN PROMOTERCPG-ISLAND METHYLATIONLUNG-CANCERDOWN-REGULATIONRISK-FACTORGENETIC EPIDEMIOLOGYFOLIC-ACID
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