File(s) under permanent embargo
Protein kinase C isozymes as potential therapeutic targets in immune disorders
Background: Members of the protein kinase C (PKC) family are key signalling mediators in immune responses, and pharmacological inhibition of PKCs may be useful for treating immune-mediated diseases. Objective: To review and discuss the insights gained so far into various PKC isozymes and the therapeutic potential and challenges of developing PKC inhibitors for immune disorder therapy. Methods: A literature review of the role of PKCs in immune cell signalling and recent studies describing immune functions associated with PKC isozyme deficiency in relevant mouse disease models, followed by specific case studies of current and potential therapeutic strategies targeting PKCs. Results/conclusion: There is vast amount of data supporting PKC isozymes as attractive drug targets for certain immune disorders. Although the development of specific PKC isozyme inhibitors has been challenging, some progress has been made. It remains to be seen if broad-scale or isozyme-selective inhibition of PKC will have clinical efficacy.
History
Journal
Expert opinion on therapeutic targetsVolume
12Issue
5Pagination
535 - 552Publisher
Informa HealthcareLocation
London, EnglandPublisher DOI
ISSN
1472-8222eISSN
1744-7631Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2008, Informa UK LtdUsage metrics
Keywords
asthmainflammationinflammatory bowel disease (IBD)kinase inhibitorprotein kinase C (PKC)rheumatoid arthritis (RA)systemic lupus erythematosus (SLE)Science & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyNF-KAPPA-BPKC-THETAT-CELLPHASE-IICATALYTIC COMPETENCEINSULIN-RESISTANCEHYDROPHOBIC MOTIFINDUCED ARTHRITISSKELETAL-MUSCLEDEFICIENT MICEArtificial Intelligence and Image Processing
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC