chatterton-psychologicaltherapies-2017.pdf (818.81 kB)
Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: network meta-analysis
journal contribution
posted on 2017-05-01, 00:00 authored by Mary Lou Chatterton, E Stockings, Michael BerkMichael Berk, J J Barendregt, Rob CarterRob Carter, Cathy MihalopoulosCathy MihalopoulosBackgroundFew trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional meta-analyses provided limited comparisons between therapies.AimsTo combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA).MethodSystematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF).ResultsCarer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combination with cognitive-behavioural therapy (CBT) significantly reduced medication non-adherence. Psychoeducation plus CBT significantly reduced manic symptoms and increased GAF. No intervention was associated with a significant reduction in depression symptom scale scores.ConclusionsOnly interventions for family members affected relapse rates. Psychoeducation plus CBT reduced medication non-adherence, improved mania symptoms and GAF. Novel methods for addressing depressive symptoms are required.
History
Journal
British journal of psychiatryVolume
210Issue
5Pagination
333 - 341Publisher
Royal College of PsychiatristsLocation
London, Eng.Publisher DOI
eISSN
1472-1465Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, Royal College of PsychiatristsUsage metrics
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