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Recent developments of nanoparticle-delivered dosage forms for buccal delivery
journal contribution
posted on 2019-11-25, 00:00 authored by Phuong TranPhuong Tran, Wei DuanWei Duan, T T D TranThe improvement of mucoadhesive buccal formulations has attracted profound interest in recent years. Drug permeability and controlled drug release via this route of administration are still a concern for effective therapy, although various strategies have been proposed. Advanced developments in nanotechnology have been investigated with promising clinical applications. The incorporation of nanoparticles in dosage forms for buccal delivery not only ensures efficient delivery but also reduces side effects to biological systems. Many approaches have been suggested to load and deliver nanoparticles containing drugs to the buccal mucosa both in topical and systemic administrations. This paper describes recent advanced concepts to include nanoparticles in dosage forms with improving drug delivery or targeting. The classification and discussion of these technologies are aimed at providing an overview of current strategies for applying controlled drug delivery. All remarkable findings will encourage innovative nanoparticle-delivered dosage forms for buccal delivery in clinical applications.
History
Journal
International journal of pharmaceuticsVolume
571Article number
118697Pagination
1 - 7Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0378-5173eISSN
1873-3476Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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Mucoadhesive buccal deliveryNanomedicineControlled drug deliveryMultilayer filmTabletScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacySOLID LIPID NANOPARTICLESCHITOSAN-COATED NANOPARTICLESBIOADHESIVE DRUG-DELIVERYMUCOADHESIVE POLYMERSIN-VITRODISSOLUTION ENHANCEMENTELECTROSPUN NANOFIBERSVIVO EVALUATIONFILMSFORMULATION
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