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Regulation of selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein
journal contribution
posted on 2004-04-09, 00:00 authored by Yuan Gao, Helen Feng, Ken WalderKen Walder, Kristy BoltonKristy Bolton, T Sunderland, N Bishara, Melissa Quick, Lakshmi Kantham, Gregory CollierSelS is a newly identified selenoprotein and its gene expression is up-regulated in the liver of Psammomys obesus after fasting. We have examined whether SelS is regulated by glucose deprivation and endoplasmic reticulum (ER) stress in HepG2 cells. Glucose deprivation and the ER stress inducers tunicamycin and thapsigargin increased SelS gene expression and protein content several-fold in parallel with glucose-regulated protein 78. The overexpression of SelS increased Min6 cell resistance to oxidative stress-induced toxicity. These results indicate that SelS is a novel member of the glucose-regulated protein family and its function is related to the regulation of cellular redox balance.
History
Journal
FEBS lettersVolume
563Issue
1-3Pagination
185 - 190Publisher
Elsevier BVLocation
Amsterdam, NetherlandsPublisher DOI
ISSN
0014-5793eISSN
1873-3468Language
engNotes
Available online 19 March 2004.Publication classification
C1 Refereed article in a scholarly journalCopyright notice
2004, ElsevierUsage metrics
Keywords
selenoproteinglucose-regulated proteinglucose deprivationendoplasmic reticulum stressgene expressionScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyBiophysicsCell BiologyOXIDATIVE STRESSHEME OXYGENASE-1GLUTATHIONE-PEROXIDASEINDUCED APOPTOSISCELLSGENEEXPRESSIONINDUCTIONPATHWAYMICEEvolutionary Biology
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