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Sequence comparison of the non-structural genes of four different types of Aleutian mink disease parvovirus indicates an unusual degree of variability
journal contribution
posted on 1994-09-01, 00:00 authored by E Gottschalck, Soren AlexandersenSoren Alexandersen, T Storgaard, M E Bloom, B AastedThe present work shows that at least four different sequence types of Aleutian mink disease parvovirus (ADV) are present in ADV isolates from mink. We here report the nucleotide sequences of these four types of ADV from nucleotide 123 to 2208 (map unit 3 to 46). This part of the genome encodes three non-structural (NS) proteins of ADV. Comparison of the deduced amino acid sequences of these NS proteins showed that the ADV proteins are much less conserved than the NS proteins from other members of the autonomous group of parvoviruses. In general, we found that the middle region of the ADV NS-1 protein was relatively well conserved among the types, while both the amino- and carboxy-terminal ends of the protein had higher amino acid variability. Interestingly, the putative NS-3 protein from type 3 ADV is truncated in the carboxy-terminal end. The molecular evolutionary relationship among the four types of ADV was examined. This analysis, taken together with the unusually high degree of variability of the ADV types, indicates that the ADV infection in mink is likely to be an old infection compared to the other parvovirus infections or, alternatively, that ADV accumulates sequence changes much faster than other parvoviruses.
History
Journal
Archives of VirologyVolume
138Issue
3-4Pagination
213 - 231Publisher
Springer WienLocation
Wien, AustriaPublisher DOI
ISSN
0304-8608Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1994, Springer-VerlagUsage metrics
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No categories selectedKeywords
Aleutian Mink Disease VirusAmino Acid SequenceBase SequenceCloning, MolecularConsensus SequenceDNA, ViralGenes, ViralGenetic VariationMolecular Sequence DataOpen Reading FramesPhylogenyPolymerase Chain ReactionSequence Homology, Amino AcidViral Nonstructural ProteinsScience & TechnologyLife Sciences & BiomedicineVirologyFELINE PANLEUKOPENIA VIRUSACUTE INTERSTITIAL PNEUMONIANONSTRUCTURAL PROTEIN NS2POLYMERASE CHAIN-REACTIONAMINO-ACID SUBSTITUTIONSCANINE HOST RANGEMINUTE VIRUSNUCLEOTIDE-SEQUENCEAUTONOMOUS PARVOVIRUSDNA-SEQUENCE
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