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Short communication: sex-linked differences in gamma-aminobutyric acid (GABA) are related to social functioning in autism spectrum disorder
journal contribution
posted on 2018-04-30, 00:00 authored by Melissa KirkovskiMelissa Kirkovski, Chao Suo, Peter EnticottPeter Enticott, Murat Yücel, Paul Bernard FitzgeraldMagnetic resonance spectroscopy (MRS) was utilized to investigate sex differences in gamma-aminobutyric acid (GABA) between adults with autism spectrum disorder (ASD) and neurotypical (NT) controls. GABA at the right superior temporal sulcus (STS) is reported for 12 ASD and 14 NT participants. The results show no group differences in GABA. There was, however, a significant positive association between GABA at the STS and autism-related social impairments in females with ASD. These findings provide preliminary support for sex differences in GABAergic distribution and processes that contribute to social functioning in ASD.
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Journal
Psychiatry research: neuroimagingVolume
274Pagination
19 - 22Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0925-4927eISSN
1872-7506Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, Elsevier B.V.Usage metrics
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