File(s) not publicly available
Solubilization of poorly water-soluble drugs using solid dispersions
journal contribution
posted on 2013-08-01, 00:00 authored by Thao T-D Tran, Phuong TranPhuong Tran, Tran N Khanh, Toi V Van, Beom-Jin LeeMany new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on improving solubility and dissolution rate of poorly water-soluble drugs. A number of patents including the most recent inventions have been undertaken in this review to address various respects of this strategy in solubilization of poorly watersoluble drugs including type of carriers, preparation methods and view of technologies used to detect SD properties and mechanisms with the aim to accomplish a SD not only effective on enhanced bioavailability but also overcome difficulties associated with stability and production. Future prospects are as well discussed with an only hope that many developments and researches in this field will be successfully reached and contributed to commercial use for treatment as much as possible.
History
Journal
Recent patents on drug delivery & formulationVolume
7Issue
2Pagination
122 - 133Publisher
Bentham Science PublishersLocation
Beijing, ChinaPublisher DOI
eISSN
2212-4039Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2013, Bentham Science PublishersUsage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC