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Solubilization of poorly water-soluble drugs using solid dispersions

journal contribution
posted on 2013-08-01, 00:00 authored by Thao T-D Tran, Phuong TranPhuong Tran, Tran N Khanh, Toi V Van, Beom-Jin Lee
Many new drugs have been discovered in pharmaceutical industry and exposed their surprised potential therapeutic effects. Unfortunately, these drugs possess low absorption and bioavailability since their solubility limitation in water. Solid dispersion (SD) is the current technique gaining so many attractions from scientists due to its effect on improving solubility and dissolution rate of poorly water-soluble drugs. A number of patents including the most recent inventions have been undertaken in this review to address various respects of this strategy in solubilization of poorly watersoluble drugs including type of carriers, preparation methods and view of technologies used to detect SD properties and mechanisms with the aim to accomplish a SD not only effective on enhanced bioavailability but also overcome difficulties associated with stability and production. Future prospects are as well discussed with an only hope that many developments and researches in this field will be successfully reached and contributed to commercial use for treatment as much as possible.

History

Journal

Recent patents on drug delivery & formulation

Volume

7

Issue

2

Pagination

122 - 133

Publisher

Bentham Science Publishers

Location

Beijing, China

eISSN

2212-4039

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2013, Bentham Science Publishers

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