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Specific changes in the M1 protein during adaptation of influenza virus to mouse

journal contribution
posted on 1995-02-01, 00:00 authored by Alister WardAlister Ward
The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. Comparison of the M gene sequences of the mouse brain adapted variants A/NWS/33 and A/WSN/33 to their parent, A/WS/33, identified two specific amino acid substitutions in the M1 protein which correlated with virulence for mouse: Ala41-->Val and Thr139-->Ala.

History

Journal

Archives of virology

Volume

140

Issue

2

Pagination

383 - 389

Publisher

Springer

Location

Vienna, Austria

ISSN

0304-8608

eISSN

1432-8798

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1995, Springer