walker-statinsandinflammation-2019.pdf (631.52 kB)
Statins and inflammation: new therapeutic opportunities in psychiatry
journal contribution
posted on 2019-03-01, 00:00 authored by Sung-Wan Kim, Hee-Ju Kang, Min Jhon, Ju-Wan Kim, Ju-Yeon Lee, Adam WalkerAdam Walker, B Agustini, Jae-Min Kim, Michael BerkMichael BerkStatins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders. In this study, we comprehensively review the literature to investigate the effects of statins on various psychiatric disorders including depression, schizophrenia, and dementia. In addition, we review adverse effects and drug interactions of statins to give clinically useful information guiding statin use in the psychiatric field. Statins seem useful in reducing depression, particularly in patients with physical disorders such as cardiovascular disease. In patients with schizophrenia, negative symptoms may be reduced by adjuvant statin therapy. Studies on cohorts at risk for dementia have generally shown protective effects of statins, while those on treatment for dementia show inconsistent results. In conclusion, statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia. Further study is required to determine optimal doses and duration of statin use for the treatment of psychiatric disorders.
History
Journal
Frontiers in psychiatryVolume
10Article number
103Publisher
Frontiers MediaLocation
Lausanne, SwitzerlandPublisher DOI
Link to full text
ISSN
1664-0640Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, Kim, Kang, Jhon, Kim, Lee, Walker, Agustini, Kim and Berk.Usage metrics
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