vijayakumar-studyprotocol-2020.pdf (864.35 kB)
Study Protocol: Transitions in Adolescent Girls (TAG)
journal contribution
posted on 2020-02-04, 00:00 authored by M E A Barendse, Nandi VijayakumarNandi Vijayakumar, M L Byrne, J E Flannery, T W Cheng, J C Flournoy, B W Nelson, D Cosme, A Mobasser, S J Chavez, L Hval, B Brady, H Nadel, A Helzer, E A Shirtcliff, N B Allen, J H PfeiferBackground: Despite recent studies linking pubertal processes to brain development, as well as research demonstrating the importance of both pubertal and neurodevelopmental processes for adolescent mental health, there is limited knowledge of the full pathways and mechanisms behind the emergence of mental illnesses such as depression and anxiety disorders in adolescence. The Transitions in Adolescent Girls (TAG) study aims to understand the complex relationships between pubertal development, brain structure and connectivity, the behavioral and neural correlates of social and self-perception processes, and adolescent mental health in female adolescents.
Methods: The TAG study includes 174 female adolescents aged 10.0 to 13.0 years, recruited from the local community in Lane County, Oregon, USA. The participants, along with a parent/guardian, will complete three waves of assessment over the course of 3 years; the third wave is currently underway. Each wave includes collection of four saliva samples (one per week) and one hair sample for the assessment of hormone levels and immune factors; an MRI session including structural, diffusion, resting-state functional and task-based functional scans; the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), a diagnostic interview on current and lifetime mental health; production of a short self-narrative video; and measurement of height, weight, and waist circumference. The functional MRI tasks include a self-evaluation paradigm and a self-disclosure paradigm. In addition, adolescents and their parents/guardians complete a number of surveys to report on the adolescent's pubertal development, mental health, social environment and life events; adolescents also report on various indices of self-perception and social-emotional functioning.
Discussion: The knowledge gained from this study will include developmental trajectories of pubertal, neurological, and social processes and their roles as mechanisms in predicting emergence of mental illness in female adolescents. This knowledge will help identify modifiable, developmentally specific risk factors as targets for early intervention and prevention efforts.
Methods: The TAG study includes 174 female adolescents aged 10.0 to 13.0 years, recruited from the local community in Lane County, Oregon, USA. The participants, along with a parent/guardian, will complete three waves of assessment over the course of 3 years; the third wave is currently underway. Each wave includes collection of four saliva samples (one per week) and one hair sample for the assessment of hormone levels and immune factors; an MRI session including structural, diffusion, resting-state functional and task-based functional scans; the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), a diagnostic interview on current and lifetime mental health; production of a short self-narrative video; and measurement of height, weight, and waist circumference. The functional MRI tasks include a self-evaluation paradigm and a self-disclosure paradigm. In addition, adolescents and their parents/guardians complete a number of surveys to report on the adolescent's pubertal development, mental health, social environment and life events; adolescents also report on various indices of self-perception and social-emotional functioning.
Discussion: The knowledge gained from this study will include developmental trajectories of pubertal, neurological, and social processes and their roles as mechanisms in predicting emergence of mental illness in female adolescents. This knowledge will help identify modifiable, developmentally specific risk factors as targets for early intervention and prevention efforts.
History
Journal
Frontiers in PsychiatryVolume
10Article number
1018Pagination
1 - 13Publisher
Frontiers MediaLocation
Lausanne, SwitzerlandPublisher DOI
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ISSN
1664-0640eISSN
1664-0640Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2020, Barendse, Vijayakumar, Byrne, Flannery, Cheng, Flournoy, Nelson, Cosme, Mobasser, Chavez, Hval, Brady, Nadel, Helzer, Shirtcliff, Allen and PfeiferUsage metrics
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Science & TechnologyLife Sciences & BiomedicinePsychiatryadolescenceMRIpubertyhormonesmental healthlongitudinalsocial processesself-developmentINDIVIDUAL-DIFFERENCESLIFETIME PREVALENCESELF-CONSCIOUSNESSGENDER-DIFFERENCESIMPLICIT THEORIESREVISED VERSIONNEGATIVE AFFECTPEER REJECTIONCO-RUMINATIONCHILDREN
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