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Synthesis and comparative physical-chemical characterisation of neutral and cationic amphiphiles using RP-HPLC
journal contribution
posted on 2013-01-01, 00:00 authored by Jennifer Suzanne Squire, Luke HendersonLuke Henderson, Xavier ConlanXavier ConlanA series of norbornane containing amphiphiles was synthesized, their lipophilicity corresponding to neutral and cationic forms was then investigated using reverse phase HPLC (High Performance Liquid Chromatography). This series of amphiphiles incorporated varied lipophilic chain length and also varied distances between the polar/cationic head group from the norbornane scaffold. Our investigation included studying the impact of the stationary phase as a replication of a membrane for both cationic and neutral amphiphiles. The choice of stationary phase was shown to be a very important consideration for this type of measurement. In this connection, C18, Cyano and Polar columns were all investigated, the cyano column was observed to be the optimal stationary phase for the comparison of both charged and neutral amphiphiles.
History
Journal
Current analytical chemistryVolume
9Issue
4Pagination
653 - 658Publisher
Bentham Science PublishersLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
1573-4110eISSN
1875-6727Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2013, Bentham Science PublishersUsage metrics
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