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Tailored mesoporous silica nanoparticles for controlled drug delivery: platform fabrication, targeted delivery, and computational design and analysis

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journal contribution
posted on 2018-01-01, 00:00 authored by Xiaodong She, Lijue Chen, Zhifeng YiZhifeng Yi, Chengpeng Li, C He, Chunfang Feng, Tao Wang, Sarah ShigdarSarah Shigdar, Wei DuanWei Duan, Lingxue KongLingxue Kong
Mesoporous silica nanoparticles (MSNs) are exceptionally promising drug carriers for controlled drug delivery systems because their morphology, pore structure, pore volume and pore size can be well tailored to obtain certain drug release profiles. Moreover, they possess the ability to specifically transport and deliver anti-cancer drugs when targeting molecules are properly grafted onto their surface. MSNs based drug delivery systems have the potential to revolutionize cancer therapy. This review provides a comprehensive overview of the fabrication, modification of MSNs and their applications in tumour-targeted delivery. In addition, the characterization and analysis of MSNs with computer aided strategies were described. The existing issues and future prospective concerning the applications of MSNs as drug carriers for controlled drug delivery systems were discussed.

History

Journal

Mini-reviews in medicinal chemistry

Volume

16

Issue

11

Pagination

976 - 989

Publisher

Bentham Science Publishers

Location

Beijing, China

ISSN

1389-5575

eISSN

1875-5607

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2016, Bentham Science Publishers