she-tailoredmesoporous-post-2016.pdf (1.47 MB)
Tailored mesoporous silica nanoparticles for controlled drug delivery: platform fabrication, targeted delivery, and computational design and analysis
journal contribution
posted on 2018-01-01, 00:00 authored by Xiaodong She, Lijue Chen, Zhifeng YiZhifeng Yi, Chengpeng Li, C He, Chunfang Feng, Tao Wang, Sarah ShigdarSarah Shigdar, Wei DuanWei Duan, Lingxue KongLingxue KongMesoporous silica nanoparticles (MSNs) are exceptionally promising drug carriers for controlled drug delivery systems because their morphology, pore structure, pore volume and pore size can be well tailored to obtain certain drug release profiles. Moreover, they possess the ability to specifically transport and deliver anti-cancer drugs when targeting molecules are properly grafted onto their surface. MSNs based drug delivery systems have the potential to revolutionize cancer therapy. This review provides a comprehensive overview of the fabrication, modification of MSNs and their applications in tumour-targeted delivery. In addition, the characterization and analysis of MSNs with computer aided strategies were described. The existing issues and future prospective concerning the applications of MSNs as drug carriers for controlled drug delivery systems were discussed.
History
Journal
Mini-reviews in medicinal chemistryVolume
16Issue
11Pagination
976 - 989Publisher
Bentham Science PublishersLocation
Beijing, ChinaPublisher DOI
ISSN
1389-5575eISSN
1875-5607Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2016, Bentham Science PublishersUsage metrics
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No categories selectedKeywords
mesoporous silica nanoparticlestargeted drug deliverycomputational designcontrolled releaseScience & TechnologyLife Sciences & BiomedicineChemistry, MedicinalPharmacology & Pharmacymesoporous silica nanoparticles (MSN)nanocarriersNITROGEN ADSORPTION DATAIN-VIVO BIODISTRIBUTIONCONTROLLED-RELEASESIRNA DELIVERYSURFACE-CHARGECANCER-CELLSCO-DELIVERYINTRACELLULAR RELEASEHOLLOW SPHERESPORE-STRUCTUREmesoporous silica\nnanoparticles (MSN)targeted drug delivery.
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